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학회지, 권호수 : MEDIATORS OF INFLAMMATION
Herbal Extract SH003 Suppresses Tumor Growth and Metastasis of MDA-MB-231 Breast Cancer Cells by Inhibiting STAT3-IL-6 Signaling
Youn Kyung Choi,Sung-Gook Cho, Sang-MiWoo,Yee Jin Yun,Sunju Park, Yong Cheol Shin, Seon-Gyu Ko
    ABSTRACT
Cancer inflammation promotes cancer progression, resulting in a high risk of cancer. Here, we demonstrate that our new herbal extract, SH003, suppresses both tumor growth and metastasis of MDA-MB-231 breast cancer cells via inhibiting STAT3-IL-6 signaling path. Our new herbal formula, SH003, mixed extract from Astragalus membranaceus, Angelica gigas, and Trichosanthes kirilowiiMaximowicz, suppressedMDA-MB-231 tumor growth and lung metastasis in vivo and reduced the viability andmetastatic abilities of MDA-MB-231 cells in vitro. Furthermore, SH003 inhibited STAT3 activation, which resulted in a reduction of IL-6 production. Therefore, we conclude that SH003 suppresses highly metastatic breast cancer growth and metastasis by inhibiting STAT3-IL-6 signaling path.

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